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Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder
Author(s) -
Nakamura Kazuhiko,
Yamada Kazuo,
Iwayama Yoshimi,
Toyota Tomoko,
Furukawa Aizou,
Takimoto Takahiro,
Terayama Hayato,
Iwahashi Kazuhiko,
Takei Nori,
Minabe Yoshio,
Sekine Yoshimoto,
Suzuki Katsuaki,
Iwata Yasuhide,
Pillai Anitha,
Nakamoto Yurie,
Ikeda Kazutaka,
Yoshii Mitsunobu,
Fukunishi Isao,
Yoshikawa Takeo,
Mori Norio
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30211
Subject(s) - panic disorder , exon , panic , missense mutation , genotype , genetics , coding region , single nucleotide polymorphism , gene , allele , biology , polymorphism (computer science) , benzodiazepine , receptor , anxiety , psychology , phenotype , psychiatry
Abstract Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5′ region, the coding region (exons 2–4), and the 3′ noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT → CAT:485G > A) resulting in an arginine‐to‐histidine (Arg → His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects ( P = 0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD. © 2006 Wiley‐Liss, Inc.