Premium
Low fetal morbidity in pregnancy associated with acute and chronic idiopathic thrombocytopenic purpura
Author(s) -
Sharon Rivka,
Tatarsky Ilana
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830460206
Subject(s) - medicine , thrombocytopenic purpura , splenectomy , pregnancy , pediatrics , obstetrics , gestation , platelet , spleen , biology , genetics
Abstract Forty‐six mothers with immune thrombocytopenic purpura (ITP) gave birth to 72 babies. Sixty‐two babies were delivered vaginally and 10 babies by cesarean section. There was no mortality among mothers or babies. Eighteen infants were born thrombocytopenic (PLT < 100 ± 10 9 /l). Eleven infants had a platelet count of less than 50 ± 10 9 /l. All the severely thrombocytopenic babies (except 1) were born to post splenectomy thrombocytopenic mothers, regardless of steroid treatment during pregnancy. Five babies had clinical manifestations of bleeding; 3 had mild purpura, 1 severe gastrointestinal bleeding, and 1 intracranial bleeding. The latter 2 babies were born prematurely to the same mother who was severely thrombocytopenic despite splenectomy in childhood. In view of very low morbidity in babies of ITP mothers, we suggest that they be delivered vaginally. Cesarean delivery should be performed in selected cases where the mother is severely thrombocytopenic despite splenectomy or where prematurity or obstetrical complications are encountered. © 1994 Wiley‐Liss, Inc.