Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes | Zendy

Yashar Vered BorenstainBen | Zendy; Barenholz Yechezkel | Zendy; HyAm Esther | Zendy; Rachmilewitz Eliezer A. | Zendy; Eldor Amiram | Zendy

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Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes

Author(s) -

Yashar Vered BorenstainBen,

Barenholz Yechezkel,

HyAm Esther,

Rachmilewitz Eliezer A.,

Eldor Amiram

Publication year - 1993

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830440114

Subject(s) - phosphatidylserine , prothrombinase , phagocytosis , thalassemia , medicine , platelet , coagulopathy , red blood cell , cardiology , immunology , thrombin , biology , membrane , genetics , phospholipid

Investigation of red blood cells from β‐thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life‐long platelet activation that are found in thalassemic patients. © 1993 Wiley‐Liss, Inc.

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