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Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft‐versus‐host disease after allogeneic peripheral blood stem cell transplant
Author(s) -
Silva Fernando,
PérezSimón José A.,
Caballero Velazquez Teresa,
Encinas Cristina,
SánchezGuijo Fermín M.,
DíezCampelo María,
Colado Enrique,
Martín Jesús,
VillanuevaGomez Fernanda,
Vazquez Lourdes,
del Cañizo Consuelo,
Caballero Dolores,
San Miguel Jesús
Publication year - 2010
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.21613
Subject(s) - medicine , immunology , graft versus host disease , stem cell , lymphocyte , peripheral blood , liver function tests , liver function , disease , biology , genetics
Chronic graft-versus-host disease (cGVHD) is the major late complication after allogeneic hematopoietic stem cell transplant [1,2]. In this article, we have analyzed the value of noninvasive day 1100 tests as predictors of severe cGVHD development in 165 patients undergoing allogeneic peripheral blood stem cell transplant (allo-PBSCT) from a matched related donor. The cumulative incidence of overall, extensive, and severe cGVHD was 67, 56, and 23%, respectively, among patients surviving >100 days after transplant. In univariate analysis, patients displaying an abnormal liver function tests (LFTs) (total bilirubin, alkaline phosphatase, and GGT > 2 times above the upper normal limit) and a low absolute lymphocyte count (ALC) (