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Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) gene polymorphism and susceptibility to non‐Hodgkin's lymphoma
Author(s) -
Monne Maria,
Piras Giovanna,
Palmas Angelo,
Arru Luigi,
Murineddu Marco,
Latte Giancarlo,
Noli Annalisa,
Gabbas Attilio
Publication year - 2004
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.20045
Subject(s) - genotype , ctla 4 , exon , lymphoma , cytotoxic t cell , biology , haplotype , immunology , gene , microbiology and biotechnology , t cell , immune system , genetics , in vitro
Abstract The CTLA‐4 molecule plays an important role in immune regulation by downregulating activation of T cells. Polymorphisms in the CTLA‐4 gene have been shown to be associated to a number of autoimmune diseases including blood disorders. In this study, the intragenic polymorphisms of the CTLA‐4 gene at position −318*C/T, +49*A/G, and the dinucleotide (AT) n repeat polymorphism in exon 3 were analyzed in patients with non‐Hodgkin's lymphoma. Genotype and haplotype analysis showed that the exon 1+49*AA genotype was over‐represented among patients with NHL ( P = 0.002), whereas no difference was observed for the −318*C/T promoter and the (AT) n polymorphisms ( P > 0.05). The data obtained indicate that the CTLA‐4+49A/G polymorphism may have a role in genetic susceptibility to NHL. Am. J. Hematol. 76:14–18, 2004. © 2004 Wiley‐Liss, Inc.