Open AccessA Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation
Author(s) -
Augurio Adriana,
Cortelletti Paolo,
Tognato Riccardo,
Rios Anne,
Levato Riccardo,
Malda Jos,
Alini Mauro,
Eglin David,
Giancane Gabriele,
Speghini Adolfo,
Serra Tiziano
Publication year - 2020
Publication title -
advanced intelligent systems
Language(s) - English
Resource type - Journals
ISSN - 2640-4567
DOI - 10.1002/aisy.201900105
Subject(s) - materials science , nanotechnology , fabrication , nanocomposite , gelatin , nanoparticle , nanomaterials , magnetic nanoparticles , nanoscopic scale , iron oxide nanoparticles , chemistry , medicine , biochemistry , alternative medicine , pathology
Herein, the fabrication of multi‐responsive and hierarchically organized nanomaterial using core‐shell SrF 2 upconverting nanoparticles, doped with Yb 3+ , Tm 3+ , Nd 3+ incorporated into gelatin methacryloyl matrix, is reported. Upon 800 nm excitation, deep monitoring of 3D‐printed constructs is demonstrated. Addition of magnetic self‐assembly of iron oxide nanoparticles within the hydrogel provides anisotropic structuration from the nano‐ to the macro‐scale and magnetic responsiveness permitting remote manipulation. The present study provides a new strategy for the fabrication of a novel highly organized multi‐responsive material using additive manufacturing, which can have important implications in biomedicine.