Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration | Zendy

Dong Chenle | Zendy; Yang Chen | Zendy; Younis Muhammad Rizwan | Zendy; Zhang Jing | Zendy; He Gang | Zendy; Qiu Xingdi | Zendy; Fu LianHua | Zendy; Zhang DongYang | Zendy; Wang Hao | Zendy; Hong Wenli | Zendy; Lin Jing | Zendy; Wu Xueqing | Zendy; Huang Peng | Zendy

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Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration

Author(s) -

Dong Chenle,

Yang Chen,

Younis Muhammad Rizwan,

Zhang Jing,

He Gang,

Qiu Xingdi,

Fu LianHua,

Zhang DongYang,

Wang Hao,

Hong Wenli,

Lin Jing,

Wu Xueqing,

Huang Peng

Publication year - 2022

Publication title -

advanced science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.388

H-Index - 100

ISSN - 2198-3844

DOI - 10.1002/advs.202102220

Subject(s) - materials science , composite number , regeneration (biology) , endometrial cancer , infertility , photothermal therapy , biomedical engineering , nanotechnology , medicine , composite material , cancer , biology , microbiology and biotechnology , pregnancy , genetics

Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near‐infrared (NIR‐II) light‐responsive shape memory composite based on the combination of cuprorivaite (CaCuSi 4 O 10 ) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly( d , l ‐lactide‐ co ‐trimethylene carbonate) (PT) as shape memory building blocks is developed. The as‐prepared CUP/PT composite possesses excellent shape memory performance under NIR‐II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability.

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