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Organocatalytic Asymmetric Michael Addition of Rhodanines to Azadienes for Assembling of Sulfur‐containing Tetrasubstituted Carbon Stereocenters
Author(s) -
Lin Wei,
Zhang Chen,
Xu Wen,
Cheng Yuyu,
Li Pengfei,
Li Wenjun
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801422
Subject(s) - stereocenter , rhodanine , chemistry , squaramide , enantioselective synthesis , michael reaction , sulfur , organocatalysis , catalysis , stereochemistry , organic chemistry , combinatorial chemistry
The squaramide catalyzed enantioselective Michael addition of rhodanines to 2‐arylidene‐ N ‐tosylbenzofuran‐3(2 H )‐imines has been established, which enables the formation of benzofurans bearing both rhodanine and sulfur‐containing tetrasubstituted stereocenter structural motif in good to high yields with good to excellent enantio‐ and diastereoselectivities.
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