Silver‐Catalyzed Isocyanide Insertion into N−H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives | Zendy

Zhang Lingjuan | Zendy; Li Juanjuan | Zendy; Hu Zhongyan | Zendy; Dong Jinhuan | Zendy; Zhang XianMing | Zendy; Xu Xianxiu | Zendy

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Silver‐Catalyzed Isocyanide Insertion into N−H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives

Author(s) -

Zhang Lingjuan,

Li Juanjuan,

Hu Zhongyan,

Dong Jinhuan,

Zhang XianMing,

Xu Xianxiu

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201701623

Subject(s) - chemistry , annulation , isocyanide , hydroxylamine , quinazoline , catalysis , ammonia , oxime , ammonium acetate , medicinal chemistry , condensation reaction , ammonium , combinatorial chemistry , organic chemistry , high performance liquid chromatography

A silver‐catalyzed [5+1] annulation of o ‐acylaryl isocyanides with ammonium acetate and hydroxlamine was developed for the efficient and practical synthesis of quinazolines and quinazoline 3‐oxides in good to excellent yields, respectively. The domino process involved an unprecedented isocyanide insertion into the N−H bond of ammonia or hydroxylamine and followed by condensation reaction at ambient conditions.

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