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Copper‐Catalyzed Preparation of γ‐Alkylidenebutenolides and Isocoumarins under Mild Palladium‐Free Conditions
Author(s) -
InackNgi Samuel,
Rahmani Raphaël,
Commeiras Laurent,
Chouraqui Gaëlle,
Thibonnet Jérôme,
Duchêne Alain,
Abarbri Mohamed,
Parrain JeanLuc
Publication year - 2009
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200800757
Subject(s) - isocoumarins , chemistry , palladium , catalysis , stereoselectivity , copper , combinatorial chemistry , organic chemistry , reaction conditions , coupling reaction
AbstractA general and efficient copper(I)‐catalyzed cross‐coupling and heterocyclization reaction of terminal alkynes and β‐iodo‐α,β‐unsaturated acid derivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5‐ylidenebutenolides and 3‐substituted isocoumarins with excellent regio‐ and stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium‐free.