Premium
Highly Enantioselective Copper‐Catalyzed Allylic Alkylation with Phosphoramidite Ligands
Author(s) -
van Zijl Anthoni W.,
Arnold Leggy A.,
Minnaard Adriaan J.,
Feringa Ben L.
Publication year - 2004
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.200303207
Subject(s) - chemistry , phosphoramidite , tsuji–trost reaction , enantioselective synthesis , allylic rearrangement , reagent , catalysis , alkylation , combinatorial chemistry , organic chemistry , oligonucleotide , biochemistry , dna
New phosphoramidites were applied as chiral ligands in the Cu‐catalyzed allylic alkylation with dialkylzinc reagents. A variety of substrates, reagents and chiral ligands were screened, resulting in improved catalytic methodology for allylic bromides in which enantioselectivities up to 88% were reached.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom