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Rapid Reversible Photoswitching of Integrin‐Mediated Adhesion at the Single‐Cell Level
Author(s) -
Kadem Laith F.,
Holz Michelle,
Suana Kristine Grace,
Li Qian,
Lamprecht Constanze,
Herges Rainer,
SelhuberUnkel Christine
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201504394
Subject(s) - adhesion , cell adhesion , integrin , materials science , azobenzene , cell adhesion molecule , biophysics , nectin , extracellular matrix , nanotechnology , focal adhesion , neural cell adhesion molecule , cell , microbiology and biotechnology , chemistry , biochemistry , biology , polymer , composite material
Rapid and reversible photoswitching of cell adhesion is achieved by c(RGDfK)‐azobenzenes embedded in a poly(ethylene glycol) background on surfaces. The light‐induced cis – trans ‐isomerization of the azobenzene enables switching of cell adhesion on the surface. Reversibility of switching over several consecutive switching cycles is demonstrated by single‐cell force spectroscopy.