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Microbubbles from Gas‐Generating Perfluorohexane Nanoemulsions for Targeted Temperature‐Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors
Author(s) -
Zhou Yang,
Wang Zhigang,
Chen Yu,
Shen Hongxia,
Luo Zhenchun,
Li Ao,
Wang Qi,
Ran Haitao,
Li Pan,
Song Weixiang,
Yang Zhu,
Chen Hangrong,
Wang Zhibiao,
Lu Guangmin,
Zheng Yuanyi
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301655
Subject(s) - microbubbles , high intensity focused ultrasound , materials science , vaporization , ablation , ultrasonography , nanotechnology , in vivo , ex vivo , biomedical engineering , computer science , ultrasound , medical physics , radiology , medicine , chemistry , microbiology and biotechnology , biology , organic chemistry
A special “small to big” temperature‐responsive phase‐transformation strategy based on the “acoustic droplet vaporization (ADV)” mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.