Three‐Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization | Zendy

Culver James C. | Zendy; Hoffmann Joseph C. | Zendy; Poché Ross A. | Zendy; Slater John H. | Zendy; West Jennifer L. | Zendy; Dickinson Mary E. | Zendy

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Three‐Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization

Author(s) -

Culver James C.,

Hoffmann Joseph C.,

Poché Ross A.,

Slater John H.,

West Jennifer L.,

Dickinson Mary E.

Publication year - 2012

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201200395

Subject(s) - library science , chemistry , computer science

An image‐guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two‐photon laser scanning photolithography. This process utilizes computational methods to directly translate three‐dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale.

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