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Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self‐Assembly, Intercellular Transport, and Dual‐Mode Cargo Delivery
Author(s) -
Lee Victor Y.,
Havenstrite Karen,
Tjio Melia,
McNeil Melanie,
Blau Helen M.,
Miller Robert D.,
Sly Joseph
Publication year - 2011
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201102371
Subject(s) - nanogel , dual mode , nanotechnology , modular design , nanoparticle , materials science , macromolecule , polymer , computer science , star polymer , dual (grammatical number) , drug delivery , chemistry , polymerization , engineering , biochemistry , aerospace engineering , composite material , operating system , art , literature
Nanogel star polymers are developed as a new route for the formation of dual‐mode nanoparticle systems for applications in the areas of synergistic therapeutic delivery, imaged therapeutic delivery, and dual‐mode bioimaging agents. These extremely uniform, structurally versatile, water‐soluble, unimolecular organic nanoparticles with tunable polyvalency and functionality are preprogrammed to spontaneously upload different types of complex functional macromolecules.