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Modification of Biomaterials with a Self‐Protein Inhibits the Macrophage Response
Author(s) -
Kim Yoon Kyung,
Que Richard,
Wang SzuWen,
Liu Wendy F.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300532
Subject(s) - engineering , engine department , mechanical engineering
A biomaterial inhibits the host immune response by displaying an endogenously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.