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High Performance, Multiplexed Lung Cancer Biomarker Detection on a Plasmonic Gold Chip
Author(s) -
Liu Bin,
Li Yaling,
Wan Hao,
Wang Lin,
Xu Wei,
Zhu Shoujun,
Liang Yongye,
Zhang Bo,
Lou Jiatao,
Dai Hongjie,
Qian Kun
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201603547
Subject(s) - detection limit , biochip , materials science , lung cancer , enolase , gold standard (test) , reproducibility , plasmon , nanotechnology , optoelectronics , pathology , medicine , chromatography , chemistry , immunohistochemistry
Diagnosis of lung cancer is performed using a plasmonic gold ( pGOLD ) chip through multiplexed near‐infrared (NIR) detection of carcino‐embryonic antigen (CEA), Cyfra21‐1, and neuron‐specific enolase (NSE) in the serum samples of patients. With ≈50‐fold enhancement of NIR fluorescence, multiplexed microarray analysis of CEA, Cyfra21‐1, and NSE in 10 μL of human serum or whole blood samples on pGOLD chip leads to markedly improved limit‐of‐quantification, limit‐of‐detection, reproducibility, and higher diagnostic sensitivity and specificity compared to traditional biochips and Luminex technology currently in use in hospitals.
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