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The splicing regulatory factor hnRNPU is a novel transcriptional target of c‐Myc in hepatocellular carcinoma
Author(s) -
Zhang Biao,
Wang HaiYang,
Zhao DeXi,
Wang DongXing,
Zeng Quan,
Xi JiaFei,
Nan Xue,
He LiJuan,
Zhou JunNian,
Pei XueTao,
Yue Wen
Publication year - 2021
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13943
Subject(s) - hepatocellular carcinoma , cancer research , rna splicing , alternative splicing , apoptosis , biology , splicing factor , liver cancer , messenger rna , gene , rna , genetics
Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is of high significance in regulating the proliferation, apoptosis, self‐renewal, and tumorigenic potential of HCC cells. Mechanismly, c‐Myc regulates hnRNPU expression at the transcriptional level, and meanwhile, hnRNPU stabilizes the mRNA of c‐MYC. We found that the hnRNPU and c‐Myc regulatory loop exerts a synergistic effect on the proliferation and self‐renewal of HCC, and promotes the HCC progression. Taken together, hnRNPU functions as a novel transcriptional target of c‐Myc and promotes HCC progression, which may become a promising target for the treatment of c‐Myc‐driven HCC.