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HIC 2, a new transcription activator of SIRT 1
Author(s) -
Song JiYang,
Lee SeungHyun,
Kim MinKyeong,
Jeon BuNam,
Cho SuYeon,
Lee SunHo,
Kim KyungSup,
Hur ManWook
Publication year - 2019
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13456
Subject(s) - activator (genetics) , downregulation and upregulation , ectopic expression , homologous chromosome , transcription factor , transcription (linguistics) , microbiology and biotechnology , chemistry , apoptosis , biology , gene , biochemistry , philosophy , linguistics
The protein deacetylase SIRT 1 is crucial to numerous physiological processes, such as aging, metabolism, and autoimmunity, and is repressed by various transcription factors, including HIC 1. Conversely, we found that HIC 2, which is highly homologous to HIC 1, is a transcriptional activator of SIRT 1 due to opposite activity of the intermediate domains of the two homologs. Importantly, this relationship between HIC 2 and SIRT 1 could be important for cardiac development, where both proteins are implicated. Here, we assessed whether ectopic expression of HIC 2, and subsequent upregulation of SIRT 1 , might decrease apoptosis in H9c2 cardiomyocytes under simulated ischemia/reperfusion (I/R) injury conditions. Our results demonstrate that unlike its structural homolog HIC 1, HIC 2 is a pivotal transcriptional activator of SIRT 1 and, consequently, may protect the heart from I/R injury.