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Monospecific anti‐GD1b IgG is required to induce rabbit ataxic neuropathy
Author(s) -
Kusunoki Susumu,
Hitoshi Seiji,
Kaida KenIchi,
Arita Masanobu,
Kanazawa Ichiro
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199903)45:3<400::aid-ana19>3.0.co;2-y
Subject(s) - sensory system , antibody , dorsum , neuroscience , chemistry , biology , medicine , anatomy , immunology
Abstract Of 22 rabbits sensitized with GD1b, 12 developed experimental sensory ataxic neuropathy. The affected rabbits had a higher level of serum IgG monospecific to GD1b than the unaffected ones. The GD1b‐positive neuronal cytoplasms of rabbit dorsal root ganglia had larger diameters than the negative ones. IgG antibody monospecific to GD1b may preferentially bind to large primary sensory neurons, causing sensory ataxic neuropathy. Ann Neurol 1999;45:400–403