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Mouse Fzd4 maps within a region of chromosome 7 important for thymus and cardiac development
Author(s) -
DeRossi Charles,
Laiosa Michael D.,
Silverstone Allen E.,
Holdener Bernadette C.
Publication year - 2000
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/1526-968x(200006)27:2<64::aid-gene30>3.0.co;2-i
Subject(s) - biology , neural crest , phenotype , embryo , heart development , fate mapping , embryogenesis , genetics , gene , anatomy , microbiology and biotechnology , embryonic stem cell
Abstract Summary: The cardiac neural crest (CNC) plays a central role in development of the thymus gland and cardiovascular system. Through morphological and histological characterization of embryos homozygous for the Del(7)Tyr c‐112K and Del(7)Tyr c‐3H albino deletions, we identified abnormalities that are consistent with aberrant development of tissues requiring CNC contributions. The defects include incompletely penetrant heart and great vessel patterning defects and hypoplastic thymus glands. The CNC phenotype is complemented by the partially overlapping deletion Del(7)Tyr c‐23DVT . Combined, these results suggest that a functional region necessary for development of CNC derived tissues is located between the Del (7) Tyr c ‐23 DVT and Del(7)Tyr c‐112K distal deletion breakpoints. This interval encompasses a functional region previously identified as important for juvenile survival (juvenile development and fertility, jdf ). Using deletion mapping, we localized the Frizzled4 ( Fzd 4) gene to the jdf /thymus and cardiac development intervals. genesis 27:64–75, 2000. © 2000 Wiley‐Liss, Inc.