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Pt II Binding to N1 of Cytosine: Strengthening the Watson–Crick Pair with Guanine and yet Confining Its pH Existence Range
Author(s) -
Brüning Wolfgang,
Sigel Roland K. O.,
Freisinger Eva,
Lippert Bernhard
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010917)40:18<3397::aid-anie3397>3.0.co;2-4
Subject(s) - guanine , cytosine , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , base pair , chemistry , aqueous solution , stereochemistry , base (topology) , nucleotide , dna , biochemistry , organic chemistry , mathematics , gene , mathematical analysis
Stronger than the natural Watson–Crick base pairing is the association between N1‐platinated cytosine and neutral, unplatinated guanine in DMSO. Nevertheless, in aqueous solution the Pt‐containing associate I (M=Pt) is stable in a narrower pH range.