Premium
Synthesis of the Globo H Hexasaccharide Using the Programmable Reactivity‐Based One‐Pot Strategy
Author(s) -
Burkhart Fred,
Zhang Zhiyuan,
WacowichSgarbi Shirley,
Wong ChiHuey
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010401)40:7<1274::aid-anie1274>3.0.co;2-w
Subject(s) - reactivity (psychology) , stereoselectivity , combinatorial chemistry , chemistry , stereochemistry , catalysis , organic chemistry , medicine , alternative medicine , pathology
Designer saccharides : The cancer antigen Globo H hexasaccharide has been synthesized from designed building blocks in a rapid, stereoselective, and high‐yielding manner by using the reactivity‐based one‐pot strategy (see scheme) guided by the OptiMer computer program. Bn=benzyl, Bz=benzoyl, ClBn= ortho ‐chlorobenzyl, NBz= para ‐nitrobenzoyl, NHTroc=2,2,2‐trichloroethylcarbamate, PMP= para ‐methoxyphenyl.