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Nonpeptidic α v β 3 Integrin Antagonist Libraries: On‐Bead Screening and Mass Spectrometric Identification without Tagging
Author(s) -
Gibson Christoph,
Sulyok Gábor A. G.,
Hahn Diane,
Goodman Simon L.,
Hölzemann Günter,
Kessler Horst
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010105)40:1<165::aid-anie165>3.0.co;2-8
Subject(s) - bead , combinatorial chemistry , chemistry , cleavage (geology) , integrin , chromatography , computational biology , biochemistry , receptor , biology , materials science , paleontology , fracture (geology) , composite material
Libraries of low molecular weight aza‐RGD mimetics were synthesized according to the split method and evaluated by on‐bead screening with a soluble integrine receptor. No coding was required because the biologically active mimetics could be identified using MS n after photochemical cleavage from the stained beads (see picture). New α v β 3 antagonists were found by this approach.