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The “Resin‐Capture–Release” Hybrid Technique: A Merger between Solid‐ and Solution‐Phase Synthesis
Author(s) -
Kirschning Andreas,
Monenschein Holger,
Wittenberg Rüdiger
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/1521-3765(20001215)6:24<4445::aid-chem4445>3.0.co;2-w
Subject(s) - polymer , reagent , solid phase synthesis , phase (matter) , molecule , chemical engineering , chemistry , materials science , combinatorial chemistry , polymer chemistry , organic chemistry , peptide , biochemistry , engineering
Abstract A polymer‐assisted organic synthesis that combines the concept of solid‐phase synthesis with the idea of polymer‐supported scavenging reagents has recently appeared on the chemistry scene. This technique has frequently been termed the “resin‐capture–release” methodology and is initiated by the immobilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in solution. This reactant plays two roles: a) the chemical alteration of the polymer‐bound intermediate and b) the simultaneous release of this reaction product from the resin back into solution. This new concept is presented and future prospects are discussed.