Premium
Pharmacotherapy for critical limb ischaemia
Author(s) -
Norgren L.
Publication year - 2000
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/1520-7560(200009/10)16:1+<::aid-dmrr108>3.0.co;2-e
Subject(s) - pharmacotherapy , medicine , critical limb ischemia , microcirculation , angioplasty , cardiology , ischemia , thrombosis , circulatory system , balloon , intensive care medicine , revascularization , myocardial infarction
Abstract Critical limb ischaemia involves a severe disturbance of both macrocirculation and microcirculation. Provided revascularisation can be performed (balloon angioplasty, bypass procedures or other reopenings), the major pharmacological problem is to reduce the risk of early thrombosis and midterm hyperplastic growth. Adjuvant treatment for the former is useful, while the latter has not yet found any specific solution. When no technical prerequisites exist for revascularisation, which means extremely deranged vascular morphology, pharmacotherapy can be tried to reduce the specific micro‐circulatory events. Results are far from good, though significant reduction of amputations and deaths may be achieved with certain drugs. Copyright © 2000 John Wiley & Sons, Ltd.