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A Concise Synthesis of an Advanced Clerodin Intermediate through a Vaultier Tandem Reaction
Author(s) -
Lallemand JeanYves,
Six Yvan,
Ricard Louis
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(20022)2002:3<503::aid-ejoc503>3.0.co;2-6
Subject(s) - chemistry , tandem , decarboxylation , natural product , combinatorial chemistry , cascade reaction , sequence (biology) , component (thermodynamics) , organic chemistry , stereochemistry , catalysis , biochemistry , materials science , composite material , physics , thermodynamics
Abstract A highly functionalised precursor of the antifeedant natural product Clerodin has been synthesised with good diastereocontrol. Key steps include a three‐component version of the Vaultier tandem sequence, and an oxidative decarboxylation with a simple experimental procedure.