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Muricenones A and B: New Degraded Pregnanes From a Gorgonian of the Genus Muricea
Author(s) -
Ortega María J.,
Zubía Eva,
Rodríguez Sonia,
Carballo J. Luis,
Salvá Javier
Publication year - 2002
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/1099-0690(200210)2002:19<3250::aid-ejoc3250>3.0.co;2-u
Subject(s) - gorgonian , chemistry , stereochemistry , oxidative cleavage , cleavage (geology) , carbon atom , nucleus , ring (chemistry) , organic chemistry , art , geotechnical engineering , coral , fracture (geology) , engineering , visual arts , catalysis , biology , microbiology and biotechnology
Abstract The gorgonian Muricea sp. contains two new degraded pregnanes, muricenones A ( 1 ) and B ( 2 ), whose structures have been defined by spectroscopic analysis. The uncommon carbon framework of muricenones may be biosynthetically derived by oxidative cleavage and loss of one carbon atom of the A‐ring of the steroidal nucleus. The new compounds, 1 and 2 , isolated from Muricea sp., selectively inhibit the growth of the A‐549 human lung carcinoma cell line. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)