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The Intramolecular Ligand‐Exchange Reaction of ( SP ‐4‐2)‐Dichlorobis(2‐hydroxyethylamine)platinum(II) and ( OC ‐6‐22)‐Tetrachlorobis(2‐hydroxyethylamine)platinum(IV), a 1 H and 15 N, 1 H‐HMQC NMR Study
Author(s) -
Galanski Mathea Sophia,
Zimmermann Wolfgang,
Baumgartner Christian,
Keppler Bernhard Klaus
Publication year - 2001
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200105)2001:5<1145::aid-ejic1145>3.0.co;2-e
Subject(s) - chemistry , platinum , intramolecular force , ligand (biochemistry) , aqueous solution , ethanolamine , chelation , inorganic chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , receptor , biochemistry
Abstract The bis(ethanolamine)platinum complexes ( SP ‐4‐2)‐dichlorobis(2‐hydroxyethylamine)platinum(II) ( 1 ) and ( OC ‐6‐22)‐tetrachlororbis(2‐hydroxyethylamine)platinum(IV) ( 2 ) have been synthesized and their chemistry in aqueous solution has been investigated due to the fact that 1 forms very stable monoadducts with 5′‐GMP. In water 1 and 2 are converted into ( SP ‐4‐3)‐chloro(2‐ethanolatoamine‐κ 2 N,O )(2‐hydroxyethylamine)platinum(II) ( 3 ) and ( OC ‐6‐31)‐trichloro(2‐ethanolatoamine‐κ 2 N,O )(2‐hydroxyethylamine)platinum(IV) ( 4 ) with a chelating ethanolatoamine ligand by a intramolecular ligand exchange reaction, which was confirmed by 1 H and 2D 15 N, 1 H‐HMQC NMR experiments and the crystal structure determination of 4 .