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A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poloxamer
Author(s) -
Chun MyungKwan,
Cho ChongSu,
Choi HooKyun
Publication year - 2000
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/1097-4628(20010222)79:8<1525::aid-app200>3.0.co;2-h
Subject(s) - poloxamer , acrylic acid , polymer chemistry , polymerization , poloxamer 407 , materials science , hydrogen bond , chemical engineering , polymer , chemistry , copolymer , nuclear chemistry , organic chemistry , composite material , molecule , engineering
Abstract A new mucoadhesive polymer was prepared by template polymerization of acrylic acid using poloxamer as a template polymer. FTIR results showed that the interpolymer complex was formed by hydrogen bonding between the carboxyl group of poly(acrylic acid) (PAA) and the ether group of poloxamer. The extent of hydrogen bonding in the PAA/poloxamer interpolymer complex increased as the ratio of PAA/poloxamer decreased. The T g of PAA/poloxamer interpolymer complexes was matched well with the T g calculated by Gordon‐Taylor's equation than that of their blends. This result suggests that the PAA and poloxamer in the interpolymer complexes are more compatible than their blends. The dissolution rate of PAA/poloxamer interpolymer complexes was much slower than that of their blends, and was dependent on the pH of the medium and the ratio of PAA/poloxamer. The adhesive bond strength of PAA/poloxamer interpolymer complexes to a plastic (polypropylene) plate was greater than their blends or a commercial product, Carbopol 971P NF. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 79: 1525–1530, 2001