Open AccessExpression of fhit protein during mouse development
Author(s) -
Falvella F. Stefania,
Menegola Elena,
Giavini Erminio,
Ottey Michelle,
Fidanza Vincenzo,
Croce Carlo M.,
Huebner Kay,
Dragani Tommaso A.
Publication year - 2000
Publication title -
the anatomical record
Language(s) - English
Resource type - Journals
eISSN - 1097-0185
pISSN - 0003-276X
DOI - 10.1002/1097-0185(20001001)260:2<208::aid-ar100>3.0.co;2-0
Subject(s) - fhit , fetus , biology , immunocytochemistry , suppressor , immunohistochemistry , endocrinology , cancer research , tumor suppressor gene , carcinogenesis , gene , immunology , genetics , pregnancy
Abstract Fhit protein has a putative tumor suppressor function in several types of human and experimental cancers. To assess whether Fhit is involved in fetal development we have examined the distribution of Fhit protein in the 12‐ through 16‐day postcoitum mouse fetus and in postnatal day 0 mouse pups by immunocytochemistry. High levels of Fhit protein were observed in the endodermal derivatives, namely, bronchi, trachea, esophagus, stomach, and intestine, in the 12‐ to 16‐day postcoitum mouse fetus and in the postnatal day 0 pup. Other tissues showed a more restricted pattern of Fhit protein expression. These results suggest that Fhit may play a role in the development of specific tissues during mouse development. Anat Rec 260:208–211, 2000. © 2000 Wiley‐Liss, Inc.