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Expression of transforming growth factor‐beta 1 in human bladder cancer
Author(s) -
Miyamoto Hiroshi,
Kubota Yoshinobu,
Shuin Taro,
Torigoe Soichiro,
Dobashi Yasushi,
Hosaka Masahiko
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19950515)75:10<2565::aid-cncr2820751025>3.0.co;2-m
Subject(s) - bladder cancer , medicine , transforming growth factor , cancer , stage (stratigraphy) , transforming growth factor beta , pathology , cancer research , oncology , biology , paleontology
Abstract Background . Elevated expression of transforming growth factor‐beta 1 (TGF‐01) has been reported in several types of human cancer. However, the significance of TGF‐β1 expression in clinical bladder cancer is not well known. Methods . The levels of TGF‐β1 expression were quantitated using a polymerase chain reaction‐based method in tissue specimens obtained from 51 patients with bladder cancer. Results . Transforming growth factor‐beta 1 expression in bladder cancer was higher than that found in normal bladder epithelium ( P < 0.01). Significantly higher levels of TGF‐β1 transcripts were observed in low and intermediate grade (Grade 1 and 2) tumors than in high grade (Grade 3) tumors ( P < 0.02). Superficial (pTa and pT1) tumors had higher levels of TGF‐β1 than invasive (pT2 or higher) tumors ( P < 0.05). Conclusions . These results suggest that enhanced expression of TGF‐β1 is specific to low grade and stage bladder cancer. Transforming growth factor‐beta 1 may play an important role in the early stages of human bladder cancer development, and TGF‐β1 expression could provide a new relevant tumor marker for determining tumor progression in patients with bladder cancer.