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Primary central nervous system T‐cell lymphoma with a predominant CD8 immunophenotype
Author(s) -
Novak Joseph A.,
Katzin William E.
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19950415)75:8<2180::aid-cncr2820750824>3.0.co;2-#
Subject(s) - immunophenotyping , pathology , lymphoma , gene rearrangement , cd5 , cd8 , southern blot , medicine , primary central nervous system lymphoma , population , immunohistochemistry , biology , flow cytometry , immunology , antigen , dna , gene , genetics , environmental health
Abstract Background. Primary T‐cell lymphomas of the central nervous system are uncommon neoplasms. Methods. A case of a primary central nervous system T‐cell lymphoma in a 66‐year‐old female who died 8 months after surgery is described. The biopsy specimen was evaluated by routine histology, immunohistochemistry, flow cytometry, and Southern blotting/DNA hybridization. Results. The neoplasm was composed of pleomorphic medium and large cells. Virtually all of the neoplastic cells reacted with antibodies to CD3, CD5, and CD8. Multiple rearranged bands were detected with the T‐cell receptor beta‐chain gene probe. Conclusion. To the authors' knowledge, this is the first description of a primary central nervous system T‐cell lymphoma composed of a predominant population of CD8‐expressing T cells, and the first case confirmed by Southern blotting/DNA hybridization.