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The utility of squamous cell carcinoma antigen for the follow‐up of patients with squamous cell carcinoma of the anal canal
Author(s) -
Petrelli Nicholas J.,
Palmer Michael,
Herrera Lemuel,
Bhargava Arvind
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920701)70:1<35::aid-cncr2820700106>3.0.co;2-e
Subject(s) - medicine , basal cell , anal canal , carcinoma , oncology , antigen , pathology , cancer research , immunology , rectum
Abstract Background . Thirty‐three patients with histologic documentation of squamous cell carcinoma (SCC) of the anal canal underwent prospective serial collection of 234 serum samples for radioimmunoassay of SCC tumor‐associated antigen. Methods . There were 23 female and 10 male patients, with a median age of 55 years. Twenty‐two of the 33 patients had multimodality therapy with radiation therapy and chemotherapy as initial treatment. Results . The median follow‐up was 22 months (range, 4‐52 months), with a median of 13 serum specimens per patient (range, 1‐23 specimens). Twenty‐eight patients currently have no evidence of disease, 4 patients are alive with disease, and 1 patient died with disease. Conclusion . In these 33 patients, the sensitivity of the SCC tumor‐associated antigen was 76%, specificity 86%, and positive predictive value 62%.