Premium
Immunoglobulin D benign monoclonal gammopathy. A case report
Author(s) -
O'Connor Michael L.,
Rice David T.,
Buss David H.,
Muss Hyman B.
Publication year - 1991
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19910801)68:3<611::aid-cncr2820680328>3.0.co;2-5
Subject(s) - medicine , immunoglobulin d , gammopathy , immunoglobulin light chain , anemia , monoclonal gammopathy of undetermined significance , immunoelectrophoresis , waldenstrom macroglobulinemia , pathology , bence jones protein , plasmacytosis , monoclonal , bone marrow , antibody , immunology , monoclonal antibody , b cell , lymphoma
Abstract The authors report a case, perhaps the first, of immunoglobulin D (IgD) benign monoclonal gammopathy. The patient, a 48‐year‐old black woman, initially had a 500 mg/dl IgD‐lambda M‐spike, hypercalcemia, and anemia. There was no bone pain, lytic bone lesions, or evidence of renal failure. The bone marrow showed 2.8% plasma cells with a diffuse (not nodular) IgD plasmacytosis and strong lambda predominance. Only trace amounts of free lambda light chains could be demonstrated by immunoelectrophoresis in serum and concentrated urine. The anemia responded quickly to iron therapy. Chemotherapy was not initiated. Over the 6+ years of follow‐up, the patient has had no progression of clinical disease attributable to her IgD monoclonal gammopathy. The IgD M‐spike has steadily decreased.