Premium
A human breast stromal sarcoma cell line with features of malignant cystosarcoma phyllodes
Author(s) -
Tibbetts Lance M.,
Poisson Marian H.,
Tibbetts Linda L.,
Cummings Frank J.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881115)62:10<2176::aid-cncr2820621018>3.0.co;2-6
Subject(s) - medicine , stromal cell , hyaluronic acid , phyllodes tumor , sarcoma , pathology , mastectomy , chemotherapy , cancer research , breast cancer , cancer , anatomy
Abstract A cell line was established from a portion of a 25‐cm stromal sarcoma of the left breast of a 65‐year‐old woman. The clinical course was rapid with tumor recurrence on the chest wall less than 1 month after mastectomy. Other cutaneous and abdominal metastases occurred shortly thereafter, and death followed within 3 months despite chemotherapy. The cultured cells, designated RW‐972, produced large amounts of acid mucopolysaccharides (hyaluronic acid) and mimicked the aggressive growth characteristics seen in the patient. After injection into nude mice, the tumor grew rapidly and occasionally produced metastases. This unique cell line, RW‐972, presumably derived from the stromal component of a human malignant cystosarcoma phyllodes, might be useful in studies of experimental therapy of this rare tumor type and of lobular stromal cells of breast. It may also be used to investigate hyaluronic acid production by tumor cells.