Premium
Significance of chromosome 14 anomaly at band 14Q11 in Japanese patients with adult T‐cell leukemia
Author(s) -
Sadamori Naoki,
Nishino Kenji,
Kusano Miyuki,
Tomonaga Yu,
Tagawa Masuko,
Yao Eiichi,
Sasagawa Ippei,
Nakamura Hideo,
Ichimaru Michito
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861115)58:10<2244::aid-cncr2820581014>3.0.co;2-t
Subject(s) - pathogenesis , medicine , leukemia , karyotype , chromosome , t cell leukemia , anomaly (physics) , chromosomal translocation , pathology , cancer research , genetics , gene , biology , physics , condensed matter physics
Abstract The chromosomes of leukemic blood cells in eight Japanese patients with acute adult T‐cell leukemia (ATL) were examined by a direct method or short‐term culture method without any mitogens. Six patients showed a chromosome 14 anomaly with a break at band q11–13: inv(14)(q11q32) in two patients, t(11;14)(p13;q13) in one patient, t(14;14)(q11;q32) in addition to del(14)(q11q13) in another, and only del(14)(q11q13) in two patients. Thus, a proximal 14q rearrangement exists in ATL as in other types of T‐cell malignancies. Based on these facts, the pathogenesis of ATL is discussed in reference to the literature.