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Malignant peripheral nerve sheath tumor arising in an adrenal ganglioneuroma in an adult male homosexual
Author(s) -
Chandrasoma Para,
Shibata Darryl,
Radin Randall,
Brown Lauren Pinter,
Koss Michael
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860515)57:10<2022::aid-cncr2820571023>3.0.co;2-d
Subject(s) - ganglioneuroma , medicine , malignant peripheral nerve sheath tumor , neuroblastoma , pathology , neoplasm , malignant transformation , peripheral nerve , metastasis , peripheral , cancer , anatomy , immunohistochemistry , biology , genetics , cell culture
Abstract The authors report a case of malignant peripheral nerve sheath tumor arising in an adrenal ganglioneuroma in an adult. This is the first such case occurring in the absence of a history of childhood neuroblastoma treated with radiation, and provides evidence that such a transformation can occur spontaneously. The neoplasm demonstrated a highly malignant biologic behavior with rapid growth, local recurrence, and metastasis.