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Chemotherapy for inoperable infantile fibrosarcoma
Author(s) -
Grier Holcombe E.,
PerezAtayde Antonio R.,
Weinstein Howard J.
Publication year - 1985
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19851001)56:7<1507::aid-cncr2820560705>3.0.co;2-7
Subject(s) - medicine , fibrosarcoma , vincristine , cyclophosphamide , chemotherapy , doxorubicin , surgery , surgical excision , radiology , pathology
Abstract Infantile fibrosarcoma, an uncommon disease of childhood, generally occurs in an extremity and despite high local recurrence rates is usually curable with surgical excision alone. Two patients whose tumors were unresectable because of extensive retroperitoneal involvement are reported. Treatment with doxorubicin, vincristine, and cyclophosphamide resulted in complete clinical responses in both patients. They remain alive and tumor free 2.5 and 4 years from diagnosis. Chemotherapy as a single modality appears to be effective in controlling unresectable infantile fibrosarcoma. Cancer 56: 1507‐1510, 1985.