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Prolactin response to thyrotropin‐releasing hormone stimulation and dopaminergic inhibition in benign breast disease
Author(s) -
Kumar Sandeep,
Mansel Robert E.,
Hughes Leslie E.,
Stuart Woodhead J.,
Edwards Catherine A.,
Scanlon Maurice F.,
Newcombe Robert G.
Publication year - 1984
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19840315)53:6<1311::aid-cncr2820530615>3.0.co;2-r
Subject(s) - medicine , prolactin , dopaminergic , thyrotropin releasing hormone , hormone , stimulation , breast cancer , endocrinology , thyroid function , disease , abnormality , physiology , cancer , dopamine , psychiatry
Abstract Pituitary function was tested in predefined clinical groups of benign breast disease under strictly controlled clinical and laboratory conditions. Two different tests of prolactin storage and control mechanisms, direct stimulation by thyrotropin‐releasing hormone (TRH) and inhibition of dopaminergic control by dom‐peridone, indicate a significant abnormality in patients with severe cyclical mastalgia and nodular breast disease ( P < 0.05 and P < 0.002), but not in those with noncyclical mastalgia. No abnormalities of thyroid function were found. Cancer 53:1311‐1315, 1984.