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T‐cell lymphoma‐leukemia. Pathologic observations in three cases
Author(s) -
Whitcomb Carence C.,
Olivella Jose E.,
Byrne Gerald E.
Publication year - 1983
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19831001)52:7<1202::aid-cncr2820520713>3.0.co;2-l
Subject(s) - medicine , lymphoma , pathology , leukemia , lymphoproliferative disorders , neoplasm , lymph , complication , immunology
Abstract A neoplastic proliferation of T‐lymphocytes with manifestations of lymphadenopathy and distinctive leukemic cells has been described recently. Histopathologic features of involved lymph nodes, are quite distinctive, but mimic some features of other lymphoproliferative disorders. The abnormal cells vary considerably in size, but are characterized by strikingly convoluted and lobulated nuclei. Hypercalcemia is a frequent complication of this neoplasm. Geographic clustering of reported cases has raised the possibility of common pathogenetic factors.