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Monomorphic adenomas of the parotid glands their ultrastructure and histogenesis
Author(s) -
Chaudhry Anand P.,
Cutler Leslie S.,
Satchidanand Sateesh,
Labay Gerald,
Raj Mary Sunder,
Lin ChengChung
Publication year - 2006
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830701)52:1<112::aid-cncr2820520121>3.0.co;2-g
Subject(s) - histogenesis , myoepithelial cell , ultrastructure , morphogenesis , pathology , ductal cells , parotid gland , anatomy , biology , salivary gland , stem cell , medicine , microbiology and biotechnology , immunohistochemistry , biochemistry , gene
Abstract Three cases of monomorphic basal cell adenoma of the parotid glands were studied with light microscopy. In one patient, fresh tissue was available for electron microscopic observations. On the basis of ultrastructural findings it was concluded that myoepithelial cells play little, if any, role in the histogenesis of this lesion. The tumor originates from the undifferentiated stem cells analogous to the cells seen at the “end bud” stage of salivary gland morphogenesis prior to their further cytodifferentiation and functional maturation into secretory and myoepithelial cells. In fully developed salivary glands such undifferentiated stem cells reside as “reserve” cells in the intercalated ductal system. Cancer 52:112‐120, 1983.