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Detection of central nervous system metastasis with cerebrospinal fluid beta‐2‐microglobulin
Author(s) -
Koch Thomas R.,
Lichtenfeld Karen M.
Publication year - 2006
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19830701)52:1<101::aid-cncr2820520119>3.0.co;2-y
Subject(s) - beta 2 microglobulin , medicine , cerebrospinal fluid , central nervous system , metastasis , pathology , lymphoma , beta (programming language) , cancer , computer science , programming language
Abstract Beta‐2‐microglobulin determinations in cerebrospinal fluid (CSF) of patients with leukemia, lymphoma, and oat cell carcinoma were performed to evaluate the utility of this test in early detection of metastasis to the central nervous system (CNS). In the presence of CNS disease, significantly higher levels ( P < 0.001) were found than in normals or patients without CNS disease. Serial measurements were performed on two patients, and in all cases beta‐2‐microglobulin became elevated coincident with CNS relapse, and returned to normal as remission was achieved. Serial testing of CSF beta‐2‐microglobulin, in patients with cancers known to invade the CNS, should facilitate prompt treatment of CNS metastasis. Cancer 52:101‐104, 1983.