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Retinoic acid‐binding protein in human squamous cell carcinomas of the ORL region
Author(s) -
Bichler Eckehard,
Daxenbichler Günter
Publication year - 1982
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19820215)49:4<619::aid-cncr2820490402>3.0.co;2-v
Subject(s) - retinoic acid , epiglottis , medicine , cell , cord , vitamin , binding site , cancer research , pathology , biology , biochemistry , cell culture , anatomy , larynx , surgery , genetics
Abstract In some squamous cell carcinomas of the otorhinolaryngologic region with different grades of differentiation, a protein was found that specifically binds vitamin A acid. In 28 of 37 tumors, the retinoic acid‐binding sites were found in significant amounts, according to the authors' data. Areas with metastases showed a lower incidence of retinoic acid‐binding, whereas in all normal epiglottis and vocal cord tissue specimens the binding was present. The possible significance of the protein‐binding for the biologic effect of the vitamin A acid is discussed.