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Correlation of prognostic factors and blood lymphocyte subtypes in non‐Hodgkin's lymphoma
Author(s) -
Murray J. Lee,
Hurtubise Paul E.,
Young Donn C.,
Balcerzak Stanley P.,
Lobuglio Albert F.
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19801015)46:8<1817::aid-cncr2820460820>3.0.co;2-c
Subject(s) - medicine , lymphocyte , lymphoma , hypogammaglobulinemia , null cell , immunology , t lymphocyte , antibody , pathology , immune system , biology , genetics , cell culture
Abstract The total lymphocyte, T, B, and null cell content of peripheral blood from 32 healthy individuals and 30 patients with non‐Hodgkin's lymphoma was determined. The patients had a significant reduction of B cells (complement receptor and membrane immunoglobulin positive cells) and a significant reduction in T cells. Correlation of patients' characteristics with lymphocyte abnormalities demonstrated several findings. Patients with advanced disease (III and IV) had significantly lower total lymphocyte and T cells than patients with localized disease (I and II) or normal controls. Patients with hypogammaglobulinemia had lower total lymphocyte and T cells than patients with normal gamma globulin status or normal controls. Patients with diffuse histology and B symptoms had lower total lymphocyte and T cells than normal controls. Discriminant analysis of lymphocyte populations categorized patients by disease extent and gamma globulin status with 70 and 68% accuracy, respectively.