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Enzyme‐linked immunosorbent assay for herpes simplex virus tumor‐associated antigen
Author(s) -
Cocchiara Roberta,
Tarro Giulio,
Flaminio Giovanni,
Gioia Mario Di,
Geraci Domenico
Publication year - 1980
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19800301)45:5<938::aid-cncr2820450517>3.0.co;2-x
Subject(s) - antigen , herpes simplex virus , antibody , radioimmunoassay , medicine , virology , enzyme , simplexvirus , immunology , virus , serology , herpesviridae , viral disease , biology , biochemistry
Abstract The antibodies against herpes simplex virus (HSV) tumor‐associated antigen (TAA) in human sera were investigated by the enzyme‐linked immunosorbent assay (ELISA). By combining the findings of antibody levels in many human sera, a significant level of discrimination between normal and cancer sera could be reached. Thus, 57 of 74 pathological sera had increased levels of antibodies against HSV‐TAA antigen as compared to 26 of 512 normal sera. A significant correlation between the ELISA values and complement fixing (CF) and radioimmunoassay (RIA) values was also found. The results suggest that serodiagnosis with the ELISA test may therefore be of some use in the detection of specific antibodies against HSV‐TAA antigen in sera of cancer patients.