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Bladder carcinoma associated with ectopic production of gonadotropin
Author(s) -
Kawamura Juichi,
Machida Shuzo,
Yoshida Osamu,
Oseko Fumimaro,
Imura Hiroo,
Hattori Masahiro
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2773::aid-cncr2820420637>3.0.co;2-9
Subject(s) - medicine , carcinoma , gonadotropin , urology , oncology , gynecology , hormone
Abstract A rare incidence of a primary gonadotropin‐producing bladder carcinoma in which gynecomastia appeared in the terminal stage was encountered in a 76‐year‐old Japanese male. There was a good probability that the symptoms of hormonal activity were due to chorionic gonadotropin (hCG), since its whole molecule, β‐ and α‐subunits were detected by radioimmunoassay in the blood, urine, and the tissue from the malignant neoplasm, and the plasma and urine estrogens were elevated. Recent papers concerning the synthesis of hCG‐like material by neoplastic cells are reviewed and the implication of the measurement of β‐ and α‐subunits of hCG in various neoplastic diseases are discussed. Other characteristic profiles of plasma hormonal levels are also discussed in this case. Cancer 42:2773–2780, 1978.