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Bronchial artery infusion with anticancer agents in the treatment of osteosarcoma. Prevention of pulmonary metastasis and improvement of prognosis
Author(s) -
Ohno Tohgo
Publication year - 1971
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197103)27:3<549::aid-cncr2820270306>3.0.co;2-f
Subject(s) - medicine , osteosarcoma , malignancy , metastasis , lumen (anatomy) , lung , surgery , pulmonary artery , radiology , cancer , pathology
Abstract Since March 1965, we have performed prophylactic infusions of the lung with anticancer agents via the bronchial arteries using a Mahajan‐Cliffton triple lumen, double balloon catheter in order to prevent pulmonary metastasis of osteosarcoma and to improve its prognosis. Prior to March 1970, we performed this procedure on 82 occasions for 35 patients with the malignancy of the limb who were found to have had no pulmonary metastasis on chest roent‐genogram at the time of the first infusion. The percentage of patients surviving 5 years by life‐table technique was 36.7%, of which the standard error was 9.9%. Complications following this procedure were observed in detail. All of the complications were negligible considering the usual poor prognosis of osteosarcoma. These results are very encouraging when compared with those obtained by our previous therapeutic regimens.