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A sequence of virus like particle formation in the ergastoplasm of greene's malignant melanoma cells
Author(s) -
Takahashi Makoto,
Mishima Yutaka
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196911)24:5<904::aid-cncr2820240507>3.0.co;2-j
Subject(s) - endoplasmic reticulum , nucleoid , virus , melanoma , hamster , particle (ecology) , virology , biophysics , biology , microbiology and biotechnology , biochemistry , genetics , ecology , escherichia coli , gene
Abstract Electron microscopic observation of Greene's melanotic and amelanotic hamster melanoma reveals distinctive particles 90‐110 μ in diameter consisting of an outer limiting membrane and an electron dense nucleoid interior 40‐50 μ in diameter, having thin spoke‐like rays. The structure of these particles is essentially identical to that of virus‐like particles found in Fortner's melanoma but differs from mature C‐type virus particles in nucleoid structure. No virus like particles were found in the liver, kidney, or skin of non‐melanoma bearing control hamsters. The sites of development of the particles are the sacs of the endoplasmic reticulum. A subcellular sequence of the development of virus‐like particles within the ergastoplasm of Greene's melanoma cells has been proposed. This sequence appears to begin with the bulging of the ergastoplasm and the aggregation of the ergastoplasmic ribosomes.