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Insecticidal activity and mode of action of 2,4‐diaminopyrimidines
Author(s) -
Wierenga Joel M,
Cullen Thomas G,
Dybas Jane A,
Henrie II Robert N,
Peake Clinton J,
Plummer M Joan
Publication year - 2000
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/(sici)1526-4998(200003)56:3<233::aid-ps120>3.0.co;2-p
Subject(s) - mode of action , tetranychus urticae , toxicology , biology , hypoxanthine , dihydrofolate reductase , pesticide , liter , spider mite , mite , biochemistry , botany , enzyme , ecology , endocrinology
Abstract Three 2,4‐diaminopyrimidines were tested against several insect species. They were active against lepidopteran pests with LC 50 values <3 mg liter −1 for most species tested. They were also active against two‐spotted spider mite, Tetranychus urticae , (LC 50 10–40 mg liter −1 ). Folinate, but not hypoxanthine or thymidine was found to be an effective rescue agent, requiring a concentration of 100 mg liter −1 diet to rescue half of the intoxicated larvae. The results confirm dihydrofolate reductase to be the site of action for these insecticides and are consistent with the mode of action of folinate rescue in mammals. © 2000 Society of Chemical Industry